Ubiquitin
نویسندگان
چکیده
منابع مشابه
Uncovering Ubiquitin and Ubiquitin-like Signaling Networks
1. INTRODUCTION Proteomes are significantly more complex than genomes and transcriptomes due to protein processing and extensive post-translational modification (PTM) of proteins. Hundreds of different modifications exist. Release 66 of the RESID database 1ferent modifications, including small chemical modifications such as phosphorylation, acetylation, and methylation and modification by small...
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Modification of cullin-RING ubiquitin ligases by the ubiquitin-like molecule Nedd8 promotes substrate ubiquitination. A crystal structure of a cullin modified by Nedd8 recently reported in Cell (Duda et al., 2008) and a biochemical study in Molecular Cell (Saha and Deshaies, 2008) reveal the dramatic impact on the ligase machinery by conjugation of ubiquitin or ubiquitin-like proteins.
متن کاملUbiquitin stripping
he Eg5 kinesin helps build a bipolar spindle by sliding microtubules past each other at the spindle midzone. On page 473, Ganem and Compton show that bipolarity requires another kinesin, called Kif2a, that localizes to spindle poles. Kif2a is strongly expressed in neuronal cells and is a member of a class of kinesins that depolymerize micro-tubules instead of stepping along their surface. The a...
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During ubiquitin conjugation, the thioester bond that links "donor" ubiquitin to ubiquitin-conjugating enzyme (E2) undergoes nucleophilic attack by the ɛ-amino group of an acceptor lysine, resulting in formation of an isopeptide bond. Models of ubiquitination have envisioned the donor ubiquitin to be a passive participant in this process. However, we show here that the I44A mutation in ubiquiti...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1990
ISSN: 0014-5793
DOI: 10.1016/0014-5793(90)81300-d